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1

Polymerization of optical isomers of phenylalanine N-carboxyanhydride by various secondary amines

Yutaka Hashimoto, Akimasa Aoyama, Yukio Imanishi, Toshinobu Higashimura

Journal:

Year:

1976

Language:

english

File:

PDF, 705 KB

english, 1976

2

Polymerization of N-carboxyanhydrides of various α-amino acids using secondary amines as initiator

Yukio Imanishi, Akimasa Aoyama, Yutaka Hashimoto, Toshinobu Higashimura

Journal:

Year:

1977

Language:

english

File:

PDF, 494 KB

english, 1977

3

Particle contamination in contrast media induced by disposable syringes

Toshiaki Sendo, Kenji Otsubo, Ayako Hisazumi, Toshinobu Aoyama, Ryozo Oishi

Journal:

Journal of Pharmaceutical Sciences

Year:

1995

Language:

english

File:

PDF, 205 KB

english, 1995

4

Intrahepatic arterial injections of cisplatin-phosphatidylcholine-lipiodol suspension in two unresectable hepatoblastoma cases

Kohji Sue, Keiichi Ikeda, Akira Nakagawara, Yumiko Hironaga, Youichi Hachitanda, Kenji Otubo, Tetsuya Mitsuishi, Toshinobu Aoyama

Journal:

Pediatric Blood & Cancer

Year:

1989

Language:

english

File:

PDF, 1.60 MB

english, 1989

5

Enantioselective determination of thiamylal in human serum by high-performance liquid chromatography

Masanori Sueyasu, Taeko Ikeda, Kenji Otsubo, Takuro Taniyama, Toshinobu Aoyama, Ryozo Oishi

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1995

Language:

english

File:

PDF, 300 KB

english, 1995

6

Determination of thiamphenicol in biological fluids by gas chromatography

Toshinobu Aoyama, Sadao Iguchi

Journal:

Journal of Chromatography A

Year:

1969

Language:

english

File:

PDF, 322 KB

english, 1969

7

Sensitive determination of ambenonium chloride in serum from patients with myasthenia gravis using ion-exchange resin extraction and reversed-phase ion-pair chromatography

Kenji Ohtsubo, Shun Higuchi, Toshinobu Aoyama, Naoki Fujii, Ikuo Goto

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1989

Language:

english

File:

PDF, 641 KB

english, 1989

8

Assay for histidine decarboxylase in rat stomach and brain by high-performance liquid chromatography with fluorescence detection

Yukitaka Nakano, Masatoshi Yamaguchi, Yasuto Tsuruta, Yosuke Ohkura, Toshinobu Aoyama, Masayoshi Horioka

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1984

Language:

english

File:

PDF, 425 KB

english, 1984

9

Clonal propagation of Cephaelis ipecacuanha

Kayo Ikeda, Daisuke Teshima, Toshinobu Aoyama, Motoyoshi Satake, Koichiro Shimomura

Journal:

Plant Cell Reports

Year:

1988

File:

PDF, 22 KB

1988

10

Production of emetic alkaloid by in vitro culture ofcephaelis ipecacuanhaA. Richard

Daisuke Teshima, Kayo Ikeda, Motoyoshi Satake, Toshinobu Aoyama, Koichiro Shimomura

Journal:

Plant Cell Reports

Year:

1988

Language:

english

File:

PDF, 420 KB

english, 1988

11

Clonal propagation ofCephaelis ipecacuanha

Kayo Ideda, Daisuke Teshima, Toshinobu Aoyama, Motoyoshi Satake, Koichiro Shimomura

Journal:

Plant Cell Reports

Year:

1988

Language:

english

File:

PDF, 528 KB

english, 1988

12

Vitamin K Prodrugs: 1. Synthesis of Amino Acid Esters of Menahydroquinone-4 and Enzymatic Reconversion to an Active Form

Jiro Takata, Yoshiharu Karube, Mitsunobu Hanada, Kazuhisa Matsunaga, Yoshikazu Matsushima, Toshiaki Sendo, Toshinobu Aoyama

Journal:

Pharmaceutical Research

Year:

1995

File:

PDF, 1.02 MB

1995

13

ANALYSIS OF THE FACTORS INFLUENCING ANTI-EPILEPTIC DRUG CONCENTRATIONS-CARBAMAZEPINE

Norio Ichikou, Ichiro Ieiri, Shun Higuchi, Kentaro Hirata, Hiroaki Yamada, Toshinobu Aoyama

Journal:

Journal of Clinical Pharmacy and Therapeutics

Year:

1990

Language:

english

File:

PDF, 568 KB

english, 1990

14

ANALYSIS OF THE FACTORS INFLUENCING ANTI-EPILEPTIC DRUG CONCENTRATIONS-VALPROIC ACID

Ichiro Ieiri, Shun Higuchi, Kentaro Hirata, Hiroaki Yamada, Toshinobu Aoyama

Journal:

Journal of Clinical Pharmacy and Therapeutics

Year:

1990

Language:

english

File:

PDF, 607 KB

english, 1990

15

Influence of Additional Therapy with Zonisamide (Excegran) on Protein Binding and Metabolism of Carbamazepine

Taketsuga Minami, Ichiro Ieiri, Kenji Ohtsubo, Yoshihiro Hirakawa, Kohji Ueda, Shun Higuchi, Toshinobu Aoyama

Journal:

Year:

1994

Language:

english

File:

PDF, 288 KB

english, 1994

16

Detection of Carbamazepine-induced Changes in Valproic Acid Relative Clearance in Man by Simple Pharmacokinetic Screening

EIJI YUKAWA, TOMOO HONDA, SHIGEHIRO OHDO, SHUN HIGUCHI, TOSHINOBU AOYAMA

Journal:

Journal of Pharmacy and Pharmacology

Year:

1997

Language:

english

File:

PDF, 526 KB

english, 1997

17

Studies on Pharmacoepidemiology of Antiepileptic Adverse Reactions (2)

Kentaro Hirata, Ichiro Ieiri, Mitsuko Kajiwara, Toshiko Kuroda, Kyoji Kojima, Manami Ikeda, Shun Higuchi, Hiroaki Yamada, Toshinobu Aoyama

Journal:

Psychiatry and Clinical Neurosciences

Year:

1991

Language:

english

File:

PDF, 210 KB

english, 1991

18

Population Pharmacokinetics of Digoxin in Japanese Patients

Professor Eiji Yukawa, Fumihiro Suematu, Miho Yukawa, Masao Minemoto, Shigehiro Ohdo, Shun Higuchi, Yoshinobu Goto, Toshinobu Aoyama

Journal:

Clinical Pharmacokinetics

Year:

2001

Language:

english

File:

PDF, 418 KB

english, 2001

19

Eudragit RS and RL (acrylic resins) microcapsules as pH insensitive and sustained release preparations of ketoprofen

Goto, Shigeru, Kawata, Masakazu, Nakamura, Masahiro, Maekawa, Kaori, Aoyama, Toshinobu

Journal:

Journal of Microencapsulation

Year:

1986

Language:

english

File:

PDF, 654 KB

english, 1986

20

Quality evaluation of radiographic contrast media in large-volume prefilled syringes and vials

Sendo, Toshiaki, Hirakawa, Masaaki, Yaginuma, Mizue, Aoyama, Toshinobu, Oishi, Ryozo

Journal:

Academic Radiology

Year:

1998

Language:

english

File:

PDF, 752 KB

english, 1998

21

Evaluation of the sustained release properties of Eudragit RS, RL and S (acrylic resins) microcapsules containing ketoprofen in beagle dogs˚

Goto, Shigeru, Kawata, Masakazu, Nakamura, Masahiro, Nagatsuma, Yoshiko, Fujinaga, Keiko, Aoyama, Toshinobu

Journal:

Journal of Microencapsulation

Year:

1988

Language:

english

File:

PDF, 1.03 MB

english, 1988

22

Eudragit E, L and S (acrylic resins) microcapsules as pH sensitive release preparations of ketoprofen

Goto, Shigeru, Kawata, Masakazu, Nakamura, Masahiro, Maekawa, Kaori, Aoyama, Toshinobu

Journal:

Journal of Microencapsulation

Year:

1986

Language:

english

File:

PDF, 634 KB

english, 1986

23

Acute Organophosphate Poisoning After Disulfoton Ingestion

Futagami, Koujiro, Otsubo, Kenji, Nakao, Yasushi, Aoyama, Toshinobu, Iimori, Emiko, Urakami, Syuichi, Ide, Michio, Oishi, Ryozo

Journal:

Clinical Toxicology (Informa Healthcare)

Year:

1995

Language:

english

File:

PDF, 333 KB

english, 1995

24

The molecular mechanism of translational control via the communication between the microRNA pathway and RNA-binding proteins

Fukao, Akira, Aoyama, Tomohiko, Fujiwara, Toshinobu

Journal:

Year:

2015

Language:

english

File:

PDF, 1.26 MB

english, 2015

25

Population-Based Investigation of Valproic Acid Relative Clearance Using Nonlinear Mixed Effects Modeling: Influence of Drug-Drug Interaction and Patient Characteristics

Yukawa, Eiji, To, Hideto, Ohdo, Shigehiro, Higuchi, Shun, Aoyama, Toshinobu

Journal:

Journal of Clinical Pharmacology

Year:

1997

Language:

english

File:

PDF, 1.08 MB

english, 1997

26

Monitoring Drug Noncompliance in Epileptic Patients

Takaki, Seiichiro, Kurokawa, Toru, Aoyama, Toshinobu

Journal:

Therapeutic Drug Monitoring

Year:

1985

File:

PDF, 329 KB

1985

27

Predictive Performance of Equations to Estimate Creatinine Clearance From Serum Creatinine in Japanese Patients With Congestive Heart Failure

Yukawa, Eiji, Hamachi, Yumiko, Higuchi, Shun, Aoyama, Toshinobu

Journal:

American Journal of Therapeutics

Year:

1999

File:

PDF, 371 KB

1999

28

Pharmacokinetic Interactions among Phenobarbital, Carbamazepine, and Valproic Acid in Pediatric Japanese Patients

Yukawa, Eiji, Hokazono, Tsuyoshi, Satou, Masayasu, Ohdo, Shigehiro, Higuchi, Shun, Aoyama, Toshinobu

Journal:

American Journal of Therapeutics

Year:

2000

File:

PDF, 3.79 MB

2000

29

Detection of Carbamazepine Drug Interaction by Multiple Peak Approach Screening using Routine Clinical Pharmacokinetic Data

Yukawa, Eiji, Aoyama, Toshinobu

Journal:

Journal of Clinical Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.04 MB

english, 1996

30

Population-Based Investigation of Relative Clearance of Digoxin in Japanese Patients by Multiple Trough Screen Analysis: An Update

Yukawa, Eiji, Honda, Tomoo, Ohdo, Shigehiro, Higuchi, Shun, Aoyama, Toshinobu

Journal:

Journal of Clinical Pharmacology

Year:

1997

Language:

english

File:

PDF, 1.31 MB

english, 1997

31

Lithium Population Pharmacokinetics from Routine Clinical Data

Yukawa, Eiji, Nomiyama, Noboru, Higuchi, Shun, Aoyama, Toshinobu

Journal:

Therapeutic Drug Monitoring

Year:

1993

File:

PDF, 563 KB

1993

32

Quality Evaluation of Commercial Lyophilized Human Growth Hormone Preparations.

KAWASHIGE, Makoto, SENDO, Toshiaki, OTSUBO, Kenji, AOYAMA, Toshinobu, OISHI, Ryozo

Journal:

Biological & Pharmaceutical Bulletin

Year:

1995

File:

PDF, 1.07 MB

1995

33

Clinical utility of a new and simple technique for individualizing phenytoin dosage.

YUKAWA, Eiji, HIGUCHI, Shun, AOYAMA, Toshinobu

Journal:

Journal of Pharmacobio-Dynamics

Year:

1989

File:

PDF, 640 KB

1989

34

Clinical Management of Boric Acid Ingestion: Pharmacokinetic Assessment of Efficacy of Hemodialysis for Treatment of Acute Boric Acid Poisoning.

TESHIMA, Daisuke, MORISHITA, Kazuo, UEDA, Yuko, FUTAGAMI, Kojiro, HIGUCHI, Shun, KOMODA, Tetsuo, NANISHI, Fumio, TANIYAMA, Takuro, YOSHITAKE, Junichi, AOYAMA, Toshinobu

Journal:

Journal of Pharmacobio-Dynamics

Year:

1992

File:

PDF, 769 KB

1992

35

Predicting serum lithium concentration using Bayesian method: A comparison with other methods.

HIGUCHI, Shun, FUKUOKA, Ryuichi, AOYAMA, Toshinobu, HORIOKA, Masayoshi

Journal:

Journal of Pharmacobio-Dynamics

Year:

1988

File:

PDF, 1.33 MB

1988

36

PEDA: A microcomputer program for parameter estimation and dosage adjustment in clinical practice.

HIGUCHI, SHUN, AOYAMA, TOSHINOBU, HORIOKA, MASAYOSHI

Journal:

Journal of Pharmacobio-Dynamics

Year:

1987

File:

PDF, 1.34 MB

1987

37

Preparation and biopharmaceutical evaluation of microcapsules of ampicillin.

GOTO, SHIGERU, UCHIDA, TAKAHIRO, AOYAMA, TOSHINOBU

Journal:

Journal of Pharmacobio-Dynamics

Year:

1985

File:

PDF, 1.33 MB

1985

38

Determination of Chloramphenicol by Gas-Liquid Chromatography

Yamamoto, Magobei, Iguchi, Sadao, Aoyama, Toshinobu

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1967

File:

PDF, 535 KB

1967

39

Pharmacological activity of propantheline bromide mixed with antacids in guinea-pigs and human.

HORIOKA, MASAYOSHI, AOYAMA, TOSHINOBU, KARASAWA, HIRONOBU

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1977

File:

PDF, 546 KB

1977

40

Effect of water on degradation of propantheline bromide mixed with dried aluminum hydroxide gel.

AOYAMA, TOSHINOBU, MAEDA, TOMOHIDE, HORIOKA, MASAYOSHI

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1977

File:

PDF, 629 KB

1977

41

Effect of drugs on erythrocytes. I. Influence of pH, osmotic pressure and a few drugs on erythrocytes' destruction.

HORIOKA, MASAYOSHI, AOYAMA, TOSHINOBU, YOKOYAMA, IKUKO, HATTA, YUMIKO

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1977

File:

PDF, 1.39 MB

1977

42

Estimation of the molecular weight of ions by isotachophoresis.

FUJISHITA, OSAMU, HIGUCHI, SHUN, YOSHIKAWA, MANABU, AOYAMA, TOSHINOBU, HORIOKA, MASAYOSHI

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1983

File:

PDF, 591 KB

1983

43

Estimation of the molecular weight of ions by isotachophoresis. II. Influence of electric charge on the precision of the correlative equations.

FUJISHITA, OSAMU, FUKUOKA, RYUICHI, HIRAKAWA, MASAAKI, HIGUCHI, SHUN, AOYAMA, TOSHINOBU, HORIOKA, MASAYOSHI

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1986

File:

PDF, 646 KB

1986

44

Barium Sulfate Crystals in Parenteral Solutions of Aminoglycoside Antibiotics

AOYAMA, TOSHINOBU, HORIOKA, MASAYOSHI

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1987

Language:

english

File:

PDF, 4.35 MB

english, 1987

45

Macromolecular complexes of drugs. I. Doxorubicin-heparin complex.

AOYAMA, TOSHINOBU, HORIOKA, MASAYOSHI, NAGAMITSU, SHINGO

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1987

Language:

english

File:

PDF, 637 KB

english, 1987

46

Estimation of the molecular weight of ions by isotachophoresis. IV. Comparison of the correlations of mobility with molecular volume and with molecular weight.

FUJISHITA, OSAMU, HIRAKAWA, MASAAKI, NAKASHIMA, KAZUHIRO, HIGUCHI, SHUN, OTSUBO, KENJI, AOYAMA, TOSHINOBU, KARASAWA, HIRONOBU

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1988

Language:

english

File:

PDF, 1.22 MB

english, 1988

47

Bayesian prediction of serum phenytoin concentration in a simulation study.

HIGUCHI, SHUN, YUKAWA, EIJI, AOYAMA, TOSHINOBU

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1988

File:

PDF, 605 KB

1988

48

Simultaneous determination of emetine and cephaeline in ipecac syrup.

TESHIMA, Daisuke, IKEDA, Kayo, SHIMOMURA, Koichiro, AOYAMA, Toshinobu

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1989

File:

PDF, 435 KB

1989

49

Clinical evaluation of population pharmacokinetic parameters in phenytoin dosage adjustment.

YUKAWA, Eiji, HIGUCHI, Shun, AOYAMA, Toshinobu

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1989

File:

PDF, 616 KB

1989

50

Population pharmacokinetics of phenytoin from routine clinical data in Japan: An update.

YUKAWA, Eiji, HIGUCHI, Shun, AOYAMA, Toshinobu

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1990

File:

PDF, 752 KB

1990

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